- Hyperthermia + Radiotherapy
- Hyperthermia + Chemotherapy
- Hyperthermia + Radiochemotherapy
- The Future
Hyperthermia and radiochemotherapy
This modality has been both investigated as well as tested in phase I/II trials concerning several advanced-stage tumors.
Trials performed on advanced esophagus cancer resulted in a better local control and an improved long term survivability (Kitamura et al, 1995 and Sughimachi et al.,1992) (figure 1).
Postoperative prognoses of advanced carcinoma of the rectum comparisons, between patients who received preoperative TM and patients undergoing surgery alone, showed significant differences in the five years survival rates (91.3% against 64.0%).
The most beneficial effect was registered in those patients presenting an advanced stage of disease (Ohno et al., 1997).
Other interesting results can be obtained from literature demonstrating that TM represents an advantage in several very complicated cases (Rau et al., 1998; Kuwano et al., 1995; Jones et al., 2004; Issels et al 1993).